Endocrine Abstracts

The activation of local renin–angiotensin–aldosterone system (RAAS) plays a pivotal role in the overall pathophysiology of the cardiovascular and renal diseases. Aldosterone can activate local renin and angiotensin converting enzyme (ACE). However, the effects of blockade of aldosterone on tissue RAAS including (pro)renin receptor and ACE2 are unclear in obese hypertensive rats induced by high-salt diet. Obese Zucker rats (ZOR) were fed with normal or high-salt diet ...

Background: The human adrenal cortex is composed of 3 distinct zones: the zona glomerulosa (ZG), the zona fasciculata (ZF), and the zona reticularis (ZR). Steroidogenic enzymes are expressed in a zone-specific manner. The promoters of CYP11B1 and CYP11B2 possess a number of target sites for DNA methylation that is closely associated with gene silencing.Methods and Materials: Adrenals from 5 autopsy subjects were assessed for immunohistrochemically define...

Background: Adrenal vein sampling (AVS) is the gold standard test for identification of unilateral primary aldosteronism (PA) which is curable by surgery, but is a difficult procedure with low success rates. Rapid cortisol assays during AVS improved AVS success rates.Methods: We have developed a gold nanoparticles based immunochromatographic quick cortisol assay (QCA) in which cortisol concentration could be measured both quantitatively and semi-quantita...